• InternationalConference& Biology

    on Hydrogen Medicine

    The 5th annual conference ofInternational Society forHydrogen Medicine & Biology

    The 14h annual conference ofJapanese Biomedical Society forMolecular Hydrogen

  • Hydrogen Molecular Medicine : Unlocking the Code of Longevity

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    The foundational paper in hydrogen molecular medicine:2007/5/7

    《Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals》

    Acute oxidative stress induced by ischemia-reperfusion or inflammation causes serious damage to tissues, and persistent oxidative stress is accepted as one of the causes of many common diseases including cancer. We show here that hydrogen (H2) has potential as an antioxidant in preventive and therapeutic applications. We induced acute oxidative stress in cultured cells by three independent methods. H2 selectively reduced the hydroxyl radical, the most cytotoxic of reactive oxygen species (ROS), and effectively protected cells; however, H2 did not react with other ROS, which possess physiological roles. We used an acute rat model in which oxidative stress damage was induced in the brain by focal ischemia and reperfusion. The inhalation of H2 gas markedly suppressed brain injury by buffering the effects of oxidative stress. Thus H2 can be used as an effective antioxidant therapy; owing to its ability to rapidly diffuse across membranes, it can reach and react with cytotoxic ROS and thus protect against oxidative damage.

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    A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives

    Keywords: Molecular hydrogen, Nutritional therapy, Diseases, Free radicals, Oxidative stress

    •Oxidative stress is responsible for the pathogenesis of many important diseases.

    •Hydrogen is a non-toxic medical gas possessing several specific biological activities.

    •Nutritional molecular hydrogen therapy is helpful for oxidative-related diseases.

    •Nutritional molecular hydrogen therapy manages the body's energy and weight.

    •Hydrogen administration can be suggested as an alternative “natural” nutritional therapy.

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    Molecular hydrogen: a therapeutic antioxidant and beyond

    Keywords:hydrogen-saturated water/saline, hydrogen gas, free radical scavenger, anti-inflammation, anti-apoptosis, biological effect, clinical application, hydrogen-oxygen nebulizer machine

    Molecular hydrogen (H2) medicine research has flourished since a landmark publication in Nature Medicine that revealed the antioxidant and cytoprotective effects of hydrogen gas in a focal stroke model. Emerging evidence has consistently demonstrated that molecular hydrogen is a promising therapeutic option for a variety of diseases and the underlying comprehensive mechanisms is beyond pure hydroxyl radicals scavenging. The non-toxicity at high concentrations and rapid cellular diffusion features of molecular hydrogen ensure the feasibility and readiness of its clinical translation to human patients.

  • Hydrogen Molecular Health : Bringing a Prosperous Life

    Can't live without oxygen; life gets better with hydrogen.

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    Hydrogen inhalation

    Using hydrogen equipment equipped with a PEM membrane electrode, 99.99% pure hydrogen is produced via pure water electrolysis technology.

    Hydrogen molecules enter the body through the respiratory system to scavenge harmful free radicals.

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    Hydrogen water drinking

    High-concentration hydrogen water is produced through physical hydrogen mixing, pure and additive-free. Hydrogen molecules enter the body through the digestive system to scavenge harmful free radicals.

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    Hydrogen Water Bathing

    High-flow, high-concentration hydrogen water is produced through physical hydrogen mixing. It can be used for face washing, bathing, and soaking. Hydrogen molecules penetrate the skin to enter the body and scavenge harmful free radicals.

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    Hydrogen-Containing Foods

    MgH₂, a hydrogen-generating material prepared using nanotechnology, reacts with water to release hydrogen molecules and magnesium ions. It can be dissolved in beverages for consumption or taken directly. While scavenging harmful free radicals, it also moderately supplements magnesium minerals required by the human body.

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